H2N2V1, 1968, Analysis, bibRecord, 000147

Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential

Identifieur interne : 000147 ( 1968/Analysis ); précédent : 000146; suivant : 000148

Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential

Auteurs : Toshihiro Ito ; J. Nelson S. S. Couceiro ; S Rge Kelm ; Linda G. Baum ; Scott Krauss ; Maria R. Castrucci ; Isabella Donatelli ; Hiroshi Kida ; James C. Paulson ; Robert G. Webster ; Yoshihiro Kawaoka [États-Unis]

Source :

Journal of Virology [ 0022-538X ] ; 1998.

RBID : PMC:109961

Abstract

Genetic and biologic observations suggest that pigs may serve as “mixing vessels” for the generation of human-avian influenza A virus reassortants, similar to those responsible for the 1957 and 1968 pandemics. Here we demonstrate a structural basis for this hypothesis. Cell surface receptors for both human and avian influenza viruses were identified in the pig trachea, providing a milieu conducive to viral replication and genetic reassortment. Surprisingly, with continued replication, some avian-like swine viruses acquired the ability to recognize human virus receptors, raising the possibility of their direct transmission to human populations. These findings help to explain the emergence of pandemic influenza viruses and support the need for continued surveillance of swine for viruses carrying avian virus genes.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC109961

PubMed: 9696833
PubMed Central: 109961

Affiliations:

Links to Exploration step

PMC:109961

Le document en format XML

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Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential

Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential

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Abstract

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